Granuloma in a glomerulus in anti-glomerular basement disease
نویسندگان
چکیده
منابع مشابه
Smiling glomerulus reveals diagnosis in seronegative anti-glomerular basement membrane disease
A 58-year-old woman with a history of tobacco use and chronic obstructive pulmonary disease was urgently referred by her family doctor for coffee-colored urine and swollen ankles since 2 days. The serum creatinine was 3.3 mg/dL, having increased from 0.9 mg/dL 1 month before. Blood pressure was 116/54 mmHg. The urine sediment showed acanthocytes and red cell casts and protein/ creatinine ratio ...
متن کاملAnti-Glomerular Basement Membrane Disease.
Anti-glomerular basement membrane (anti-GBM) disease is a rare small vessel vasculitis that affects the capillary beds of the kidneys and lungs. It is an archetypic autoimmune disease, caused by the development of directly pathogenic autoantibodies targeting a well characterized autoantigen expressed in the basement membranes of these organs, although the inciting events that induce the autoimm...
متن کاملRituximab in anti-glomerular basement membrane disease.
The role of rituximab has expanded beyond the treatment of non-Hodgkins lymphoma, to include successful management of rheumatoid arthritis, systemic lupus erythematosus, anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis and primary glomerulonephritis. Decrease incidence of side-effects or toxicity, coupled with clinical effectiveness, suggests that B-cell depleting agents may ...
متن کاملAtypical anti-glomerular basement membrane disease.
BACKGROUND Anti-glomerular basement membrane (anti-GBM) disease classically presents with aggressive necrotizing and crescentic glomerulonephritis, often with pulmonary hemorrhage. The pathologic hallmark is linear staining of GBMs for deposited immunoglobulin G (IgG), usually accompanied by serum autoantibodies to the collagen IV alpha-3 constituents of GBMs. METHODS Renal pathology files we...
متن کاملAdvances in the genetics of anti-glomerular basement membrane disease.
Anti-glomerular basement membrane (GBM) disease is a rare but lethal autoimmune disorder. Over the past few years, the nature of the autoantigen and its epitopes has been defined, as well as the possible pathogenic role played by environmental factors, and by cellular and humoral immunity. However, the majority of data on anti-GBM disease comes from studies conducted on animal models, since hum...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: CEN Case Reports
سال: 2018
ISSN: 2192-4449
DOI: 10.1007/s13730-018-0353-y